This post by Randall Wood explains a lot when it comes to where to publish and why. And if he is correct ( haven’t read this any place else so I’m a wee-bit skeptical), he also explains why their additional distribution channels do little to actually sell more of your books. I don’t know where he got his figures from, but they are very interesting.
The only thing I would add is, I would print in one additional place – from a brick and mortar printer of your choice. Most do POD nowadays.
Many Indie books stores do take self-published books (usually at a 40% discount) but since Createspace takes 50-55% anyway (I heard it was 50% if you published through createspace and 55% if you printed it yourself and you sell it on Amazon yourself), you’re way ahead in the profit category if the indie bookstore takes a book you had printed yourself.